The Wimbledon and Olympic Singles champion was beaten in five sets by Kei Nishikori, going down 1-6, 6-4, 4-6, 6-1 and 7-5 to the sixth seed.
The Japanese number one will play either Stan Wawrinka or Juan Del Potro in the semi-finals.
The result is a reversal of the Olympic singles semi final where Murray came out victor, going on to win gold and defend his Olympic crown.
Murray was looking to become part of an elite group to make all four grand slam finals in a year, having been runner up and the Australian and French Opens alongside his Wimbledon crown.
The Japanese number one will play either Stan Wawrinka or Juan Del Potro in the semi-finals.
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Murray in action in this year's US Open - BBC Sport |
Murray was looking to become part of an elite group to make all four grand slam finals in a year, having been runner up and the Australian and French Opens alongside his Wimbledon crown.
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